scholarly journals Survival trend after invasive cervical cancer diagnosis in sweden before and after cytologic screening. 1960–1984

Cancer ◽  
1994 ◽  
Vol 73 (1) ◽  
pp. 140-147 ◽  
Author(s):  
Hans-Olov Adami ◽  
Jan Pontén ◽  
PÄR Sparén ◽  
Reinhold Bergström ◽  
Leif Gustafsson ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Cancer Diagnosis ◽  
Invasive Cervical Cancer ◽  
Before And After

scholarly journals Underscreened Women Remain Overrepresented in the Pool of Cervical Cancer Cases in Spain: A Need to Rethink the Screening Interventions

2015 ◽  
Vol 2015 ◽  
pp. 1-9 ◽  
Author(s):  
Raquel Ibáñez ◽  
María Alejo ◽  
Neus Combalia ◽  
Xavier Tarroch ◽  
Josefina Autonell ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Older Women ◽  
Cancer Diagnosis ◽  
Invasive Cervical Cancer ◽  
Previous History ◽  
Figo Stage ◽  
Normal Cytology ◽  
Highly Sensitive ◽  
History Of ◽  
Screening History

Objective. Audit of women with invasive cervical cancer (CC) is critical for quality control within screening activities. We analysed the screening history in the 10 years preceding the study entry in women with and without CC during 2000–2011.Methods. 323 women with CC from six pathology departments in Catalonia (Spain) and 23,782 women with negative cytology were compared. Age, previous history of cytologies, and histological type and FIGO stage were collected from the pathology registries. Logistic regression analysis was used to estimate odds ratios (OR) and 95% confidence intervals (CI95%).Results. History of cytology was registered in 26.2% of CC cases and in 78% of the control women (P<0.0001) and its frequency decreased with increasing age. Compared to women with squamous cell carcinoma, adenocarcinoma cases were significantly more likely to have a cytology within the 3-year interval preceding cancer diagnosis (OR=2.6CI 95%: 1.2–5.6) and to have normal cytology results in previous screenings (OR=2.4CI 95%: 1.2–4.5). FIGO II–IV cases were more common among older women (older than 60 years).Conclusions. Absence of prior screening history was extremely common among CC cases compared to controls. Organized actions to reduce underscreened women and use of highly sensitive HPV-based tests could be important to reduce CC burden.

scholarly journals Screening Plasma Exosomal RNAs as Diagnostic Markers for Cervical Cancer: An Analysis of Patients Who Underwent Primary Chemoradiotherapy

Biomolecules ◽  
2021 ◽  
Vol 11 (11) ◽  
pp. 1691
Author(s):  
Oyeon Cho ◽  
Do-Wan Kim ◽  
Jae-Youn Cheong
Keyword(s):  
Cervical Cancer ◽  
Pathway Analysis ◽  
Cancer Diagnosis ◽  
Healthy Individuals ◽  
Cancer Group ◽  
Before And After ◽  
Primary Chemoradiotherapy ◽  
Preliminary Study ◽  
Non Coding Rnas ◽  
Exosomal Rnas

This preliminary study aimed to screen non-coding RNAs (ncRNAs) from plasma exosomes as a new method for cervical cancer diagnosis. Differentially expressed RNAs were initially selected from among a group of 12 healthy individuals (normal group) and a pretreatment group of 30 patients with cervical cancer (cancer group). Then, we analyzed the association between an ncRNA-mRNA network and cancer using ingenuity pathway analysis after secondary selection according to the number and correlation of mRNAs (or ncRNAs) relative to changes in the expression of primarily selected ncRNAs (or mRNAs) before and after chemoradiotherapy. The number of RNAs selected from the initial RNAs was one from 13 miRNAs, four from 42 piRNAs, four from 28 lncRNAs, nine from 18 snoRNAs, 10 from 76 snRNAs, nine from 474 tRNAs, nine from 64 yRNAs, and five from 67 mRNAs. The combination of miRNA (miR-142-3p), mRNAs (CXCL5, KIF2A, RGS18, APL6IP5, and DAPP1), and snoRNAs (SNORD17, SCARNA12, SNORA6, SNORA12, SCRNA1, SNORD97, SNORD62, and SNORD38A) clearly distinguished the normal samples from the cancer group samples. We present a method for efficiently screening eight classes of RNAs isolated from exosomes for cervical cancer diagnosis using mRNAs (or ncRNAs) altered by chemoradiotherapy.

Successful changes in the diagnosis of earlier stages in invasive cervical cancer following a cancer detection program in Tucuman, Argentina

2007 ◽  
Vol 25 (18_suppl) ◽  
pp. 1544-1544
Author(s):  
J. J. Zarba ◽  
S. V. Holgado ◽  
M. Sanchez Segura ◽  
A. Gonzalez ◽  
V. Audi ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Low Income ◽  
Precancerous Lesions ◽  
Invasive Cervical Cancer ◽  
Staging System ◽  
Effective Control ◽  
Papanicolaou Test ◽  
Cross Sectional ◽  
Before And After ◽  
The Impact

1544 Background: The PDCCUT provides annually free cancer screening to many low-income, underinsured women. Effective control of cervical cancer depends primarily on early detection of precancerous lesions and also on the diagnosis of earlier stages of invasive lesions through use of the Papanicolaou test, followed by timely evaluation and treatment. The goal of this study is to determine the impact of the PDCCUT on the stage at initial diagnosis of invasive cervical cancer. Methods:This is a retrospective, cross-sectional and exploratory study of data registered in CRRCGMT from 376 women with cervical cancer diagnosis. UICC/FIGO is the staging system used. Every 3 years -from 1985 to 2005- rates were calculated; also trend of stages I-IIa and IIb-IV were estimated. Patients-stages were analyzed, before and after 2001 (beginning of the program). Changes in cervical cancer rates before and after the introduction of organized screening were compared. Conclusion: The results showed a progressive increase in the diagnosis of earlier stages of cervical cancer indicating the impact of PDCCUT. The last trienium rate is coincident with the increase of citological diagnosis (Papanicolaou). A lower rate in the diagnosis of EIIb-IV stages is expected in the next trienium. Evaluation of clinical practice in a Cancer Program allows to improve asistencial quality. [Table: see text] [Table: see text] No significant financial relationships to disclose.

Human papillomavirus genotype and prognosis of invasive cervical cancer: A nationwide cohort study.

2019 ◽  
Vol 37 (15_suppl) ◽  
pp. 5525-5525
Author(s):  
Jiayao Lei ◽  
Alexander Ploner ◽  
Camilla Lagheden ◽  
Carina Eklund ◽  
Sara Nordqvist Kleppe ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Human Papillomavirus ◽  
High Risk ◽  
Cancer Diagnosis ◽  
Excess Mortality ◽  
Invasive Cervical Cancer ◽  
Low Risk ◽  
Female Population ◽  
Hpv Status ◽  
High Risk Hpv

5525 Background: The role of human papillomavirus (HPV) in development from oncogenic infection to invasive cervical cancer (ICC) has been well established. However, the association of HPV genotypes and prognosis of ICC is controversial. Methods: We identified all ICC diagnosed in Sweden during the years 2002-2011 (4254 confirmed cases after clinical and histo-pathological review), requested all archival formalin-fixed, paraffin-embedded blocks and subjected them to comprehensive HPV genotyping. Twenty out of twenty-five archives agreed to the study, contributing a total of 2845 confirmed cases with valid HPV results. Cases were followed up from date of cancer diagnosis to 31 December, 2015, migration from Sweden, or death; whichever occurred first. Five-year relative survival ratios (RSRs) were calculated and excess hazard ratios (EHRs) with 95% confidence intervals (CIs) were estimated using Poisson regression. Results: HPV was detected in 2365 tumors (83.1% of all cases). The five-year RSR by tumor HPV status was 0.54 (HPV negative), 0.76 (HPV16 positive), 0.73 (HPV18 positive), 0.72 (other high-risk HPV positive) and 0.56 (low-risk HPV positive) compared to the age-matched general female population. Compared to cases with HPV-negative tumor, a significantly lower excess mortality was seen if the tumor was positive for HPV16 (EHR:0.54, 95% CI 0.44-0.65), other high-risk HPV (EHR:0.47, 95% CI 0.37-0.60), and low-risk HPV (EHR:0.48, 95% CI 0.32-0.74), after adjustment for age, time since cancer diagnosis, International Federation of Gynecology and Obstetrics (FIGO) stage, educational level and histology. However, the mortality among women with HPV18 positive tumors were not statistically significantly different from cases with HPV-negative tumors. In women with a single HPV infection of either HPV16 or HPV18, those with HPV18-positive tumors had 56% (EHR:1.56, 95% CI: 1.13-1.97) higher excess mortality compared to women with HPV16-positive tumors. Conclusions: HPV genotype in cervical cancer tumor is associated with prognosis of ICC. Single HPV18 positivity indicated a poorer prognosis than single HPV16 positivity. This could add information of value beyond the established clinical prognostic factors for women diagnosed with ICC.

scholarly journals Pengaruh Psikokuratif terhadap Kadar VEGF-c, Kortisol dan Skor HADS Pasien Kanker Serviks Stadium Lanjut

2020 ◽  
Vol 7 (1) ◽  
pp. 58
Author(s):  
Soetrisno Soetrisno ◽  
Sri Sulistyowati ◽  
Rubin Enhui Tjiang ◽  
Hari Wujoso ◽  
Hafi Nurinasari ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Cancer Diagnosis ◽  
Intervention Group ◽  
Advanced Stage ◽  
Advanced Cervical Cancer ◽  
Group Design ◽  
Intervention Method ◽  
Before And After ◽  
The Mean ◽  
Cancer Diagnosis And Therapy

Background: Cancer diagnosis and therapy that causes chronic stress, its progression to depression  increase cortisol and VEGF-c levels in advanced cervical cancer patientsObjective: To  know the VEGF-c, cortisol and HADS level  in advanced stage cervical cancer patients who get Psychocurative intervention Method : An experimental study of pretest – posttest controle group design in outpatient oncology clinic and ward of Doctor Moewardi General Hospital. Thirty subjects with advanced cervical cancer were randomly divided into 15 patients in the intervention group, and 15 in control. Psycho-curative intervention 4 times a month, 1 time a week, 60 minutes duration. Before and after intervention, each subject of the two groups was examined levels of VEGF-c, cortisol and HADS scores. Data obtained were analyzed by independent t test, Mann Whitney, Pair t and Wilcoxon with the 19th version of SPSS for Windows.Result and Discussion: Average VEGF-c levels before intervention 9006.53 ± 2181.49, after intervention 5631.20 ± 2071.55, p <0.001. The mean cortisol level before intervention was 12.29 ± 4.36, after intervention 6.71 ± 3.88, p <0.001. The mean HADS Anxiety score before intervention was 14.13 ± 3.02, after intervention 8.47 ± 3.07, p <0.001. Mean Depression HADS scores before intervention 13.80 ± 3.21, after intervention 7.20 ± 2.70, p <0.001.Conclusion : VEGF-c levels, cortisol, HADS anxiety scores and depression in patients with advanced cervical cancer decline after psychocurative intervention. Keywords : Psychocurative; VEGF-c; Cortisol; HADS; Cervical cancer

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